Press releases

The aim is to strengthen the competitiveness of Italian businesses and promote the growth of a dynamic and future-oriented entrepreneurial ecosystem through the co-creation of innovative solutions developed by startups, spin-offs and innovative SMEs in response to the needs of medium and large enterprises. With this ambitious goal and as part of the activities and services of IP4FVG – EDIH, Area Science Park, in collaboration with ELIS Innovation Hub, is launching the Open Innovation@IP4FVG, programme through two calls: Call 4 Need, for medium and large enterprises, and Call 4 Solution, dedicated to startups, spin-offs and innovative SMEs. Thanks to the programme, the selected companies will work together, for 12 weeks, on the co-development of a Proof of Concept (PoC), a pilot project or prototype that makes it possible to test the innovative solutions and assess their effectiveness, applicability and scalability. Every stage of the approach will be guided and supported by experts from Area Science Park and ELIS Innovation Hub, through to final validation of the solution. Thanks to PNRR funds from the IP4FVG-EDIH project, selected medium and large enterprises will have access to subsidised funding of up to 80% to develop their PoC with a value of €40.000 each. The co-innovation approaches must focus on advanced digital technologies for optimising processes across the entire value chain, for reducing environmental impact and for cybersecurity. The programme includes a first local service event on 15 April at 3 p.m. in the Pasolini Room of the Friuli Venezia Giulia Region in Udine, during which companies and startups can join the programme, meet, delve deeper into the topic of Open Innovation and take part in networking sessions aimed at fostering long-term collaborations. The programme is part of the IP4FVG-EDIH services, an initiative funded by the National Recovery and Resilience Plan (PNRR) – Mission 4, Component 2 (M4C2) – Investment 2.3, subsidised by the European Union – Next Generation EU, which aims to encourage the adoption of digital and green technologies. More information on the areas and the approach is available at this link. To register for the presentation event on April 15 in Udine, click here.

China is the most attractive market for patents in the rare earth element (REE) recycling sector, with a significantly higher number of patent applications compared to other countries. This is what emerges from the study “Innovation in rare earths recycling: A quantitative and qualitative analysis of patent data”, which, through a meticulous analysis of patent data, offers an in-depth examination of innovation in the Rare Earth recycling sector. Rare earth elements are fundamental for the digital transition and decarbonisation and are used in key technologies such as batteries, wind turbines and electronic devices. However, their extraction has a significant environmental impact and the supply chain is highly concentrated in just a few countries, making recycling a strategic solution to ensure sustainable access to these resources, reduce dependence on imports and limit the environmental impact of mining activities. According to the study, published in Resources Policy and conducted by Area Science Park (Riccardo Priore and Marinella Favot) and the University of Milan-Bicocca (Marco Compagnoni), China remains the most dynamic market in the REE recycling sector and Chinese universities are the main players in innovation, demonstrating a strong commitment to research and development of new technologies for the recovery of these materials. However, the United States and Japan emerge as technological leaders, with patents that are more frequently mentioned and with greater international protection of their inventions, indicating more advanced and globally relevant technological innovation. Europe, on the other hand, shows signs of stagnation in both the number and quality of patents. To bridge the gap with the main players in the sector, greater support for innovation is needed through public investment, business incentives and international collaborations. Moreover, revising policies for managing waste of electric and electronic equipment (WEEE), which is rich in critical raw materials, is crucial to making the circular economy more effective, by improving waste collection, enhancing recycling facilities and incentivising the use of secondary raw materials. Riccardo Priore of the Patlib Centre, at Area Science Park, states that “This study represents an innovative type of support, through statistical analysis of patent documents, to various issues related to academic research activities. The study of innovation dynamics in the rare earth recycling sector provides an important starting point for developing more effective strategies in the REE recycling sector, with significant implications for the strategic autonomy of importing countries and for the future of the global circular economy.” In a context of increasing demand for rare earth elements, recycling capacity will become increasingly crucial in reducing dependence on imports and mitigating the environmental impact of extraction. The results of the study suggest that, in order to remain competitive, Western countries should intensify their efforts in the recycling sector by promoting high-quality innovations and investing in the transition to a more sustainable economy. Link to the paper 

To achieve the “zero emissions” target, emerging technologies such as green hydrogen are essential. However, the production of green hydrogen through electrolysis depends on critical raw materials (CRM), for which the demand is increasing, while supply remains concentrated in just a few countries. The study was presented at the “IRTC25: From Raw Material Policies to Practice” conference held in Ljubljana, supported by EIT RawMaterials (European Union) and the Federal Department of Economic Affairs (Switzerland). The research, conducted by Area Science Park (Riccardo Priore and Marinella Favot) and the University of Milano-Bicocca (Marco Compagnoni) within the North Adriatic Hydrogen Valley project – NAHV, explored two key aspects: technological innovation in green hydrogen through the analysis of patents and the assessment of the criticality of the raw materials necessary. To identify global trends in green hydrogen innovation, patents related to key technologies such as fuel cells and electrolysers were analysed. Additionally, the criticality of the raw materials necessary for these technologies was assessed based on the EU’s list of critical raw materials. Thanks to the PatLib Centre at Area Science Park, the study used a patent database (PATSTAT) covering the period from 2000 to 2023, focusing on: temporal trends in patents for fuel cells and electrolysers countries with the strongest interest in intellectual property protection on these topics the most used critical raw materials and their trends over time. The picture that emerged is the following: patent applications for hydrogen technologies have increased significantly, reaching 5,380 applications filed in 2022 (a figure that may continue to grow), making a total of over 45,600 applications from 2000 to 2023 (noting that the publication secrecy period for applications is 18 months); China, Japan and the USA are the territories most interested in the legal protection (via patents) of the production or commercialisation of key green hydrogen technologies; 13% of patents mention at least one critical raw material, with Nickel, Platinum and Lithium as the most important for both technologies (fuel cells and electrolysers). The researchers conclude that while the increase in patent applications highlights a global push towards green hydrogen-based solutions, the dependency on critical raw materials such as Nickel, Platinum and Lithium raises concerns about supply risks, price volatility and geopolitical dependencies. To ensure the sustainable growth of hydrogen technologies, it will be crucial to develop new research into alternative materials and, at the same time, effective recycling strategies and supply chains.

An innovative solution for the recovery and reuse of yttrium, a rare and critical chemical element, from electronic waste, has emerged from research conducted by Area Science Park and the University of Udine, presented at the “IRTC25” conference in Ljubljana. The study, conducted by Marinella Favot, Roberta Curiazi and Antonio Massarutto, demonstrates how Yttrium Triflate (Y(OTf)₃), a widely used catalyst in the pharmaceutical industry, can be produced in a cost-effective and environmentally friendly way from waste materials. Yttrium and its compounds play a crucial role in numerous chemical and technological processes within the pharmaceutical sector. This element is used as a catalyst in key reactions for the synthesis of pharmaceutical intermediates, such as hydrolysis, condensation and oxidation-reduction reactions. Thanks to its high efficiency, yttrium triflate, in particular, makes it possible to reduce reaction times and improve chemical process yield, making it indispensable for the production of complex molecules that form the basis of many medicines. As well as its use as a catalyst, yttrium is used in advanced technologies such as solid-state lasers, used in medical devices for surgery and diagnostics (YAG – Yttrium Aluminium Garnet lasers), in medical imaging techniques (including positron emission tomography – PET) and in biocompatible materials used in medical devices. Additionally, yttrium is used in the production of ceramics, LCD (Liquid Crystal Display) and plasma screens, cathode ray tubes (CRT), automotive catalysts, fluorescent lamps, permanent magnets and metallic alloys for batteries, as well as in fuel cells and electrolysers (key green hydrogen technologies), primarily in the form of yttria-stabilised zirconia (YSZ).   Recycling Yttrium from Electronic Waste: A Sustainable Solution The research presented at the “IRTC25” conference focuses on recovering yttrium oxide, which is present in small quantities in electronic waste, and transforming it into yttrium triflate through a three-stage process: catalyst synthesis, filtration and water removal. Although the final product is not 100% purified, it has proven to be effective and economically sustainable compared to purchasing pure yttrium triflate on the market. “The recycling process not only reduces dependence on virgin raw materials but it also represents a cost-effective solution”, explains Marinella Favot of Area Science Park. “In fact, recovering yttrium from electronic waste is more cost-effective than traditional disposal methods, especially when the price of the recovered material exceeds the costs of collection and treatment.” This research has been selected for a pitch at Apple and McKinsey’s “Talent meets Industry” event and represents a significant step towards a more sustainable circular economy, reducing the environmental and social impact linked to rare earth extraction and improving the resilience of supply chains. However, some challenges remain, such as the volatility of the prices of pure materials and the need to develop infrastructures for the treatment of electronic waste in Europe. In a global context where the demand for critical materials such as yttrium is constantly increasing, the recycling of electronic waste is confirmed as a key strategy for ensuring a more sustainable future and reducing environmental impact, also in pharmaceutical production.

A guideline to support European local and regional authorities in drafting, implementing and monitoring territorial plans that integrate aspects of energy, climate and mobility, aimed at achieving climate neutrality in a multilevel governance perspective. It was drawn up by the IN-PLAN project team, co-funded by the European Union’s LIFE Programme, to support local authorities who often struggle to convert climate objectives into concrete actions. The IN-PLAN methodology suggests an integrated and collaborative approach combining sectoral plans (e.g. renewable energy, sustainable mobility and climate adaptation) and urban plans in a single spatial planning strategy. It also encourages collaboration among local, regional and national levels of government, fostering greater coherence and the allocation of adequate resources for climate actions. All this is in line with European initiatives, such as the Green Deal and the EU Climate Law, in support of the objectives of reducing emissions and achieving climate neutrality. There are several key elements in the IN-PLAN Guidelines, co-created, developed and tested with 15 local authorities in Italy, Croatia, Ireland, Romania and Sweden, and now being implemented and spread to another 30 European municipalities: Integrated planning: it incorporates energy and climate objectives in spatial development plans, addressing key issues such as sustainable mobility, renewable energy and climate adaptation; Political commitment: it ensures collaboration among local, regional and national governments to obtain long-term support and dedicated resources for sustainable initiatives, with a view to multi-level governance; Skill building: it provides a two-phase training programme first for energy and climate agencies and consultants, who will then assist local and regional governments in developing their own spatial plans, thus guaranteeing knowledge transfer and replicability of the IN-PLAN model across Europe; User-friendly checklists: The checklists guide municipalities in the process of integrating energy and climate objectives into their spatial plans, making sure that effective measures to achieve climate neutrality are planned and implemented. “As climate change continues to present unprecedented challenges, it is crucial that local governments have tools available that are not only aligned with national and EU policies, but that also respond to the specific needs of their territories,” explains Fabrizia Salvi of Area Science Park. “Despite ambitious climate neutrality goals, many local and regional authorities face persistent challenges in converting these goals into concrete actions.” As the European Union strives to achieve climate neutrality by 2050, a tool like the IN-PLAN practice provides towns and regions with the tools they need to actively take steps towards a sustainable future, ensuring that climate goals are not only set, but also achieved through concrete and integrated actions. This support tool is already being tested with 15 local and regional authorities, called “Lighthouses”, and 30 more municipalities will be involved as “Pilots”, making it possible to adapt and replicate the methodology all across Europe. The Municipality of Prato, which is taking part in the European mission “100 Climate-Neutral and Smart Cities by 2030”, is working on the harmonisation of the new Municipal Structural Plan with the Sustainable Urban Mobility Plan according to the measures indicated in the Climate City Contract. “In 2022, a governance structure was defined to coordinate urban planning, mobility and energy that developed policy measures for drafting the Climate City Contract – explains architect Riccardo Pallini, manager of the Mobility and Infrastructure Sector -. These indications were also the basis for drafting the new Structural Plan and a new Sustainable Urban Mobility Plan (SUMP); in this way, the theme of sustainable mobility was already present in the guidelines for the drafting of the new Structural Plan, and the new SUMP of the Municipality of Prato can thus be developed in close relation with the indications of the Structural Plan and the Climate City Contract”. Interdepartmental collaboration has begun in Narni to deal with the challenges of complexity. “It is important for medium-small municipalities to have the opportunity to learn good practices, even if implemented in large municipalities, which then need to be adapted to the local situation, striving to remove some administrative barriers,” says Giovanni Rubini, Council member for Environmental Policies. There is a need for cultural change and simplified regulations; we need skills, a long-term vision, the possibility of establishing contacts with the Regions and Ministries, and a central coordination role for the provinces. The availability of resources is also a problem and if we want to encourage the development of monitoring plans, rewards should be provided that favour the most virtuous Municipalities.” The city of Padua is also committed to implementing ambitious integrated plans to achieve climate neutrality by 2030. “Data and a cross-sectoral approach are needed in order to address the challenges of implementing these plans,” says Giovanni Vicentini, technical official with the Environment and Territory Sector. The Municipalities do not have all the data and usually, even within these municipalities, each departmental area has data that could be useful to others. Data is essential for developing a detailed overview, and the barriers are not technological.” The Guideline will also be further explored within the National Round Table for Discussion (National Coalition Group) of the IN-PLAN project, an activity launched in December 2024, offering a unique opportunity for various stakeholders to exchange views and make recommendations on integrated planning to be subsequently shared with national policy-makers. Participation in the Round Table, which does not require any formal membership, is conceived as an open space for discussion and debate and foresees further online meetings during 2025. The IN-PLAN Guideline is available here. Further information about the IN-PLAN project is available here.

Scientific collaboration between Italy and Serbia is being strengthened. The Minister of University and Research, Anna Maria Bernini, and the Serbian Minister of Science, Technological Development, and Innovation, Jelena Begović, inaugurated the second Italy-Serbia Scientific Forum in Trieste at Area Science Park, with the participation of over 100 researchers from both countries. Following a bilateral meeting, the ministers signed a joint declaration confirming the importance of cooperation in research and innovation, based on the MoU signed in Belgrade in 2023, as well as the promotion of researcher mobility, support for joint research programs, and bilateral scientific events. The document also highlighted the great success of the first call for joint research projects focused on the following areas: High Performance Computing and Big Data, Artificial Intelligence, Agri-food Technologies, and Sustainable Economy. Over 80 applications were received and are currently under evaluation. The selected projects will be co-financed by both countries (for a total of 2 million euros) at the beginning of 2025. Today’s event continues the path started in March 2023 in Belgrade when Area Science Park participated in the first edition of the Science Forum. In December 2023, during the Innovation Forum, a Memorandum of Understanding was signed in the capital between Area Science Park and the science and technology parks of Belgrade, Niš, Čačak, and Novi Sad. This memorandum further develops a longstanding cooperation with Serbia that began in 2015, focusing on technical assistance in the fields of technology transfer and economic development. The goal is to pool scientific and technological capacities, such as those generated by research infrastructures and technological platforms, for example, on topics like life sciences, energy transition, and innovative materials. “The Italy-Serbia scientific forum represents, for Area Science Park and for the entire Scientific and Innovation System of Friuli Venezia Giulia, an important opportunity to strengthen collaboration between the two countries and create new opportunities for the exchange and sharing of knowledge and best practices,” said Caterina Petrillo, President of Area Science Park. “In particular, for the institution I lead, hosting, and especially participating in the forum, means expanding the areas of exchange and dialogue with research centers, universities, and science and technology parks, with which we have previously developed innovation projects. Today, our attention is focused on research and technological infrastructures, where Area has been investing in recent years, which by their nature are places for aggregation and sharing of knowledge.”

A robotic device that uses ultrasound technology to treat liver cancer, one of the world’s leading causes of death, with over 900,000 cases every year. The Pisa-based startup Soundsafe Care has won first prize in the 2024 Startup Marathon. The startup competition, promoted by Area Science Park, UniCredit and Fondazione Comunica, ended on Tuesday, 26 November, with an event hosted at the UniCredit headquarters in Milan. Ten finalists were selected by a jury of entrepreneurs, investors and industry experts, from a pool of over 60 startups and innovative SMEs, enrolled in the competition by incubators, accelerators, research centres and universities all over Italy. Awards for Startups Operating in the artificial intelligence, innovative materials, nutraceutical, agritech, healthcare, gaming, electric mobility and medical innovation sectors, the ten startups competed for access to the UniCredit Start Lab acceleration programme. The overall winner, Soundsafe Care, is a company supported by the Navacchio Technology Hub. Using focused ultrasound, the device developed by the startup provides a non-invasive and drug-free alternative for the treatment of liver cancer, reducing complications and hospital costs. Thanks to advanced imaging and automation technology, the device improves treatment precision and reduces intervention times. Soundsafe Care also received the award for the best predominantly female startup, guaranteeing participation in the BoostHerUp internationalisation programme, promoted by Area Science Park. In second place was another med-tech startup, Impavid from Turin, nominated for the contest by G-Factor, the Fondazione Golinelli business incubator. Impavid develops an innovative biodegradable cardiac patch to combat post-ischaemic heart failure. This biomimetic and bioresorbable patch recreates the structure of myocardial tissue, promoting cell recovery and adapting to the heart’s rhythm. Initially designed for bypass procedures, it offers a safer and less invasive solution to improve patients’ quality of life. With strong potential in the US and European markets, the product responds to the growing demand for advanced cardiology technologies. Ranked third, the Lecce-based BeadRoots – supported by Eatable Adventures – develops a natural and biodegradable hydrogel derived from algae. This hydrogel efficiently retains and releases water to improve agricultural productivity and reduce water wastage, especially in areas affected by drought. Unlike synthetic products, the gel is eco-friendly and supports soil microorganisms without negative impacts. The startups on the podium will have the opportunity to enjoy privileged access to the pre-selection stage for the national mission at CES in Las Vegas. Awards for support organisations The top three business support organisations that nominated startups for the event were also rewarded. Points were assigned based on the ranking of the startups, with a bonus for the placement of predominantly female startups. The first prize went to the Polo Tecnologico di Navacchio, followed by G-Factor in second place and Eatable Adventures in third place. All three were granted privileged access to the Executive MBA in Business Innovation created by the MIB Trieste School of Management. This same recognition was awarded individually to all 10 finalist startups. The 2024 edition also introduced the Open Innovation B2B competition, which challenged startups and innovative SMEs to respond to specific innovation needs indicated by corporate partners of the initiative. “We are very pleased with this fifth edition of Startup Marathon”, said Roberto Pillon, head of the Business Generation Office at Area Science Park. “The startups selected for the finals operate in very diverse sectors, showing how innovation is a cross-cutting element in every market and how initiatives like this can support its development. Today, the transformative capabilities of technology, with the even greater potential of the deep-tech sector, have an enormous impact on every industry: a scenario that can be expressed in full through close collaboration between producers of innovation and businesses capable of leveraging it.” Renzo Chervatin, head of Territorial Development for UniCredit North Est, stated: “There are many reasons to feel satisfied with the 2024 edition of Startup Marathon, particularly the creation of a virtuous ecosystem made up of corporate companies, investors and numerous accelerators and incubators at the national level. As UniCredit, we have made available the know-how gained in over a decade as pioneers and leaders supporting the world of Italian startups, with the intent of reaffirming, in practice, our commitment to work alongside those who want to invest in innovation, by proposing growth opportunities to businesses and jobs to young people.” Gianni Potti, President of Fondazione Comunica and founder of DIGITALmeet, added: “This is a brilliant demonstration of digital literacy, one of the biggest challenges for the country. In addition to this, there are also innovation and entrepreneurial skills, requirements that the Jury used for the 2024 edition of Startup Marathon: as of September, there were 16,500 innovative startups in Italy; at the same time, there were nearly 200 thousand in Europe, concentrated in the technology, sustainability, digital health and artificial intelligence sectors. Startups are a fundamental driving force for the future, thanks to their ability to innovate, adapt and transform entire sectors.” “This is yet another demonstration of an idea that turned out to be spot on”, commented Antonio Bassi and Maurizio Caradonna, founders of Startup Marathon, “The Startup Marathon final, attended by a high-profile audience, showcased entrepreneurial ventures with great opportunities for development and teams with high-level skills and technological knowledge, supported by organisations that aim to create high-potential businesses throughout the nation. We are proud to have contributed, even in a small way, to encouraging the growth of this innovation ecosystem”.  Startup Marathon was founded in 2020 and, over the years, it has selected and rewarded innovative companies operating in sectors such as artificial intelligence, diagnostics, IoT and sustainability. Winners of past editions include Katakem, a spin-off of the University of Catanzaro, that accelerates the development of new molecules, CAEmate, a company that has developed software for the predictive maintenance of infrastructures, Aisent, which provides services based on AI, machine learning and computer vision, and M2Test, a spin-off of the University of Trieste that has created an innovative method for diagnosing osteoporosis. Partners In addition to the three promoters, several partners support Startup Marathon, including Angel For Women, ASAC, Avvio Capital, Bando Easy, Camst Group, Carel, Chiesi, CRCLEX, DBA Group, Eatable Adventures, ELIS Innovation Hub, Eurotherm, Fastweb, FITT, Galdi, Giordano Controls, HiRef, Italian Angels for Growth, Italian Business Angels Network, LIFTT, Manni Group, Master Builders Solutions, Mastercard, Maxfone, MIB Trieste School of Management, MITO Tech Ventures, One Factory, San Marco Group, Star Tech Ventures, Step, Unicorn Trainers Club, Venture Factory and WDA.   The Finalist Startups and their Supporting Organisations BeadRoots, Lecce, supported by Eatable Adventures Cartesia Solutions, Pisa, supported by Digital Hub Impavid, Turin, supported by G-Factor InnoItaly, Codognè (Treviso), supported by Trentino Sviluppo Joule, Campodarsego (Padua), supported by Seedble Northern Light Composites, Monfalcone (Gorizia), supported by TEC4I FVG NuHpro, Rimini, supported by CesenaLab SoundSafe Care, Pisa, supported by Polo tecnologico di Navacchio Weabios, Pisa, supported by Polo tecnologico di Navacchio Witty Power, Bolzano, supported by NOI Techpark   Startup Marathon is a competition for innovative businesses, open to startups, innovative SMEs and university spin-offs nominated by business incubators and accelerators. Promoted by Area Science Park, UniCredit and Fondazione Comunica, it has been selecting the most significant innovative Italian companies since 2020, accelerating their go-to-market journey.

An international study, involving the Italian National Research Council (CNR – Istituto Officina dei Materiali) and the Universities of Trieste and Milano-Bicocca for Italy, along with the University of Vienna, has unveiled a simple and innovative method for creating a new category of materials. These materials combine the exceptional properties manifested by individual metal atoms with the robustness, flexibility and versatility of graphene, for potential applications in the fields of catalysis, spintronics and electronic devices. The study is published in Science Advances: the method involves depositing metal atoms, such as cobalt, in a controlled manner, during the formation of the graphene layer on a nickel surface. Some of these atoms are incorporated into the carbon network of graphene, forming a new material with exceptional robustness, reactivity and stability. The method was developed at the CNR-IOM laboratories in Trieste: “This is still a preliminary result, but it is already very promising and the result of an original idea that arose in our laboratory and initially seemed unfeasible,” says Cristina Africh, a researcher at the CNR-IOM who led the team. The material’s ability to detach from the substrate while maintaining its original structure makes it potentially usable in various applications. “The methodology has been tested for trapping nickel and cobalt atoms, but our calculations suggest that it could be extended to other metals for different applications,” explains Cristiana Di Valentin, professor of General and Inorganic Chemistry at the University of Milano-Bicocca. Moreover, the material has proven to be stable even under critical conditions. “We have demonstrated that this material remains intact even in critical conditions, including the electrochemical environments used for applications in fuel cells and batteries,” adds Jani Kotakoski of the University of Vienna. The study, which is the result of international collaboration, made use of different and complementary skills. “This aspect was decisive in demonstrating the effectiveness of this approach, which is simple and powerful at the same time,” concludes Giovanni Comelli from the University of Trieste.

The Data Engineering Laboratory (LADE) at Area Science Park has recently published an innovative study into Bioinformatics, opening up new perspectives in the study of proteins, the fundamental building blocks of life. In fact, Francesca Cuturello, Marco Celoria, Alessio Ansuini and Alberto Cazzaniga, the authors of the study, have demonstrated how artificial intelligence can predict the impact of genetic mutations on protein stability, helping to get a better understanding of the mechanisms underlying many diseases and potentially developing new treatments. The genome of living beings is constantly mutating due to external agents or random events and this leads us to observe changes in the sequences of the proteins they synthesise. Conducted as part of the Pathogen Readiness Platform for CERIC-ERIC (PRP@CERIC) project, the study uses AI models similar to GPT, applied to proteomics. These models are based on the analogy between a protein sequence and a sentence, with amino acids acting as “words”, allowing algorithms trained on hundreds of millions of protein sequences to be applied. Using this technique, the LADE researchers were able to predict how small variations in the amino acid sequence, such as those induced by mutations, can affect protein stability. A particularly innovative aspect is the use of the MSA Transformer model, which utilises information on the ancestral relationships between protein sequences to enhance the accuracy of predictions. The algorithm developed by LADE offers cutting-edge performance and will be made available to the scientific community to encourage further advancements in this field. “Predicting the effect of protein mutations through artificial intelligence allows us to explore, with great precision, complex biological phenomena that, until recently, were difficult to observe directly”, explains Francesca Cuturello, the study’s lead author. “This technology is a step forward towards innovative therapeutic solutions for a wide range of diseases.” The team’s work has already received widespread recognition, including Francesca Cuturello’s invitation to the prestigious Research Retreat “Physics of Biological Data Analysis” at the Aspen Center for Physics and it will be presented at other international research centres, such as the ICTP and the Leibniz Center for Informatics. For more information about LADE’s activities, click here.

Science and training can effectively contribute to developing the strategic partnership between Italy and Africa, also in light of the new Mattei Plan for Africa promoted by the Presidency of the Council of Ministers. This is demonstrated by Friuli Venezia Giulia, which, with the significant amount of experience gained and success stories, can play a central role in deepening the already fruitful collaborations. This is what emerged from the annual conference of SiS FVG, the Scientific and Innovation System of Friuli Venezia Giulia, held on Wednesday, 26 June, at Trieste’s Area Science Park and which explored the connections between international cooperation and scientific diplomacy. “The Scientific and Innovation System of Friuli Venezia Giulia has anticipated many of the topics in the Mattei Plan. The very topic of scientific diplomacy has gone hand in hand with the history of this territory, anticipating the debate we are facing at a national and European level”, declared Alessia Rosolen, Councilor for work, training, education, research, university and family of the Autonomous Region of Friuli Venezia Giulia. “Our added value has concerned, in particular, the training courses in support of research, in the relationship between new professional figures, in the construction of the higher education system and ITS (Higher Technical Institutes). In this area, among other things, we have two national excellences: The exchange programme of the “Malignani” Institute of Udine with Egypt and that of ITS “Alto Adriatico” of Pordenone with Ghana. During the conference, there were talks by numerous speakers, making contributions to and discussing the topic. Among these, Vincenzo Lorusso, in charge of the European Union’s Cooperation in Research and Innovation with the African Union at the Directorate-General for Research and Innovation of the European Commission, spoke about the key role that Research & Innovation have in the development of the partnership between the European Union and Africa. Lorusso also confirmed the investment (equal to 150 billion euros), announced at the EU-AU summit last February, aiming to support Africa for a strong, inclusive, ecological and digital recovery and transformation. The role of science as an effective tool for consolidating transnational relations was already reiterated in the 2019 Trieste Declaration, signed by the ministers of 17 countries of the Central European Initiative (CEI), who designated as priorities themes such as scientific diplomacy, the mobility of researchers, the exchange of staff, and the promotion of transnational collaborative networks. Among the best practices presented are the MITS Academy/Egypt project and Alto Adriatico Confindustria’s training project with Ghana. The former, stemming from the collaboration between the ITS Academy of Udine and the Istituto Paritario Don Bosco of Cairo, and illustrated by Paola Perabò, Vice President of the MITS Malignani Istituto Tecnico Superiore Foundation of Udine, aims at reducing the misalignment between supply and demand of qualified personnel in the manufacturing sector and promoting cooperation between Italy and Egypt. The latter, presented by the President of the Alto Adriatico Confindustria, Michelangelo Agrusti, has the objective of training young Ghanaians, already enrolled in technical and professional schools in that country, to fill the labour shortage in the industrial system of Friuli Venezia Giulia. The President of Area Science Park, Caterina Petrillo, opened the meeting, focusing on the strategic importance of the topic of the Conference, shared by all the representatives of SiS FVG, “a fundamental theme for Trieste, a centre of excellence where numerous entities were created and operate and are active in research and higher education at an international level”. The President then remembered the G7 Research event on 2 October, organised in the context of the BSBF 2024, devoted to building skills and transferring knowledge in order to strengthen collaboration between Italy and Africa. Alessandro Garbellini – Office Manager of the Space, Multilateral Scientific Cooperation and Intellectual Property Department of the Ministry of Foreign Affairs and International Cooperation, then spoke, and affirmed: “The SiS FVG model certainly represents a lever for our foreign policy and is proof of how much a functioning infrastructure combined with proactivity of the institutions brings benefits to the nation’s system. Trieste has invented a new model of scientific cooperation: pooling skills, allowing access and ensuring that brains produce regardless of their origin. The Ministry is promoting the Trieste model around the world.” This was followed by a speech by Francesco Ciardiello, of the Technical Administrative Office of the General Directorate of Research at the Ministry of University and Research, who reiterated Trieste’s central position and the role that it can play in the development of international cooperation. The final part of the conference was dedicated to a round table moderated by Nico Pitrelli, director of the Master’s Programme in Science Communication of the “Franco Prattico” SISSA. The discussion focused on cases of scientific cooperation and diplomacy presented by various institutions of the SiS FVG. Speakers: Alessandro Lombardo, Senior Executive Officer CEI – Central European Initiative; Marianna Maculan, External Relations Manager for ICGEB – International Center for Genetic Engineering and Biotechnology; Atish Dabholkar, Director of ICTP – International Centre for Theoretical Physics; Tonya Blowers, Programme Coordinator of OWSD – Organization for Women in Science for the Developing World; Claudia Baracchini, Senior Project Manager of TEC4I FVG – Technologies for innovation FVG; Peter Mc Grath, Coordinator of the Scientific Diplomacy Unit for TWAS – The World Academy of Sciences; Mounir Ghribi – Director of International Cooperation and Research Promotion for OGS – National Institute of Oceanography and Experimental Geophysics. Councilor Rosolen concluded the work. SiS FVG is an initiative of the Autonomous Region of Friuli Venezia Giulia, in collaboration with the Ministry of Foreign Affairs and International Cooperation and the Ministry of University and Research, to enhance the Scientific and Innovation System of Friuli Venezia Giulia.

Regenerative Symphony, the installation created following the artist residency in Area Science Park, was presented during the fifth edition of the New Atlas of Digital Arts, an international event that took place from 20 to 21 June at the MEET Digital Culture Center in Milan, and which aims at promoting and investigating digital creativity scenarios, highlighting the potential of immersive creative experiments as possible drivers of cultural, social and economic innovation. During the event, part of the S+T+ARTS in the City project, in addition to the presentation of the work, a series of European institutions and actors participated, offering an overview of the state-of-the-art and technological developments related to immersive experiences. With Regenerative Symphony, the German artist Daria Jelonek, and the Englishman Perry-James Sugden, of Studio Above&Below created an interactive audiovisual installation generated by an artificial intelligence model that uses self-analysis, mineral monitoring, and market analysis of the northern region of Italy as input data to recognise, decide on, and predict the output of an immersive modular installation. The work was created thanks to the direct involvement of Area Science Park researchers who collaborated with the artists during the weeks of residency, providing them with inspiration, materials and resources starting from their own research. In particular, the teams from the LAME Laboratory were involved; they illustrated their research results in the field of innovative materials and nanotechnologies; Francesca Cuturello and Tommaso Rodani from the LADE Data Engineering Laboratory were also involved, and along with them, the artists actually elaborated the mathematical model underlying the immersive work. Furthermore, during the weeks of residency in Area Science Park, the artists drew inspiration from a visit to the Elettra Sincrotrone laboratories, where they heard from the researchers about the Institution’s most challenging research projects in the materials sector. “Regenerative Symphony is a work of art that explores a future (2030-2050) in which critical minerals, rare elements essential for modern technologies, are recycled instead of extracted – explain the authors – This scenario challenges current difficulties in the recycling of these minerals. The installation uses a model of artificial intelligence that works with data from synthetic and natural materials to visualize this regenerative future. The work of art manifests itself as a generative projection, which reveals the beauty of reuse through the metaphor of sound symphonies. Visitors can interact with the installation, adjusting the view through predictive data of material resources on an iPad.” The public can, in fact, interact with the work by creating new objects, starting with the recycling of others and thanks to sustainable energy sources. The AI ​​model reacts to requests, identifying various solutions, including recycling critical materials from unused e-waste or making alternative design decisions. During computation, the digital experience in the space is rearranged, leading to a new and different immersive environment. Confirming how our every gesture can have a concrete impact on the health of our Planet.

A team of Italian researchers published a study in the Annals of Hepatology that represents a significant advancement in transplant medicine. The study sheds light on the molecular mechanisms that influence the success of liver allografts. The Italian Liver Foundation Onlus, the Liver Transplant Centre of the “Friuli Centrale” University Health Authority and Area Science Park with the Genomics and Epigenomics Laboratory worked together to write the article. It gives a thorough look at how genomics and epigenomics affect transplanted liver. Allograft – the transplant of organs or tissues between two individuals of the same species – involves rejection risks due to the recipient’s immune system recognising the transplanted tissue as foreign. The study focuses on how variations at the genomic and epigenomic levels – the latter is a field that examines changes in gene expression that do not involve changes in the DNA sequence – can influence the recipient’s response and the outcome of the transplant. The results of the study provide new insight into how transcriptomic changes, that is, changes in the transcription of DNA into messenger RNA, can contribute to the initial damage to the transplanted liver, the recurrence of chronic disease, or organ rejection. This research opens up new perspectives for preventing these complications, thus improving the chances of the success of liver allografts and the quality of the patients’ life. “The project – states Pablo Giraudi of the Italian Liver Foundation – involved the collection, at the time of surgery, of liver biopsies and blood samples from patients who have undergone a transplant due to various chronic liver diseases (including liver cirrhosis due to viral infections such as hepatitis C and B, alcoholic cirrhosis, cirrhosis associated with non-alcoholic steatohepatitis and cryptogenic cirrhosis) and the use of DNA and RNA obtained from the respective biopsies. Analyses with specific bioinformatic platforms allow us to obtain information on the expression of genes that is useful in a personalized therapy and diagnostic/prognostic biomarkers”. “This project – explains Danilo Licastro, head of the Genomics and Epigenomics Laboratory of Area Science Park – allowed us to apply our research knowledge in an integrated and organic way. Our laboratory produced and analysed information regarding RNA sequence and the status of DNA methylation for all the samples provided by our partners. The result of this scientific project was only possible because of the high degree of collaboration between the two research structures, and it constitutes a fundamental step towards continuing on from research towards clinical-diagnostic application on a large scale. We are confident that the results of this experimentation will be the starting point for further studies also involving other international institutes”. “This is a pioneering experimental research project – affirms the scientific Director of the FIF, Claudio Tiribelli – which, by generating big data, will make it possible to create databases that will be useful for initiating collaboration in digital health based on artificial intelligence models towards a more personalized type of medicine, such as, for example, the use of immunosuppressants which are more suitable to the patient, in order to avoid rejection of the transplanted organ. It is also proof that the interaction between scientific and clinical realities makes it possible to achieve high-level results.” “Area Science Park’s choice to enhance investment in cutting-edge laboratories and technologies increases internal skills in the Life Sciences sector and strengthens collaboration with research institutions on large projects of common interest that have a significant social impact, ” declared the President of Area Science Park, Caterina Petrillo. “The achievement of the established objectives – states the President of the FIF, Decio Ripandelli – will lead to the continuation of the important relationships among the various bodies involved, for the definition of new directions in national and international research and the training of highly specialised human resources, with a consequent increase in local and foreign collaboration”.