Press releases
All news from Area Science Park
27.03.2025
Open Innovation@IP4FVG: two Calls open to Medium and Large Enterprises, startups, spin-offs and innovative SMEs
The aim is to strengthen the competitiveness of Italian businesses and promote the growth of a dynamic and future-oriented entrepreneurial ecosystem through the co-creation of innovative solutions developed by startups, spin-offs and innovative SMEs in response to the needs of medium and large enterprises.
With this ambitious goal and as part of the activities and services of IP4FVG – EDIH, Area Science Park, in collaboration with ELIS Innovation Hub, is launching the Open Innovation@IP4FVG, programme through two calls: Call 4 Need, for medium and large enterprises, and Call 4 Solution, dedicated to startups, spin-offs and innovative SMEs.
Thanks to the programme, the selected companies will work together, for 12 weeks, on the co-development of a Proof of Concept (PoC), a pilot project or prototype that makes it possible to test the innovative solutions and assess their effectiveness, applicability and scalability.
Every stage of the approach will be guided and supported by experts from Area Science Park and ELIS Innovation Hub, through to final validation of the solution. Thanks to PNRR funds from the IP4FVG-EDIH project, selected medium and large enterprises will have access to subsidised funding of up to 80% to develop their PoC with a value of €40.000 each.
The co-innovation approaches must focus on advanced digital technologies for optimising processes across the entire value chain, for reducing environmental impact and for cybersecurity.
The programme includes a first local service event on 15 April at 3 p.m. in the Pasolini Room of the Friuli Venezia Giulia Region in Udine, during which companies and startups can join the programme, meet, delve deeper into the topic of Open Innovation and take part in networking sessions aimed at fostering long-term collaborations.
The programme is part of the IP4FVG-EDIH services, an initiative funded by the National Recovery and Resilience Plan (PNRR) – Mission 4, Component 2 (M4C2) – Investment 2.3, subsidised by the European Union – Next Generation EU, which aims to encourage the adoption of digital and green technologies.
More information on the areas and the approach is available at this link.
To register for the presentation event on April 15 in Udine, click here.
Innovation services
Press releases
12.03.2025
Rare Earth Recycling and patents
China is the most attractive market for patents in the rare earth element (REE) recycling sector, with a significantly higher number of patent applications compared to other countries. This is what emerges from the study “Innovation in rare earths recycling: A quantitative and qualitative analysis of patent data”, which, through a meticulous analysis of patent data, offers an in-depth examination of innovation in the Rare Earth recycling sector.
Rare earth elements are fundamental for the digital transition and decarbonisation and are used in key technologies such as batteries, wind turbines and electronic devices. However, their extraction has a significant environmental impact and the supply chain is highly concentrated in just a few countries, making recycling a strategic solution to ensure sustainable access to these resources, reduce dependence on imports and limit the environmental impact of mining activities.
According to the study, published in Resources Policy and conducted by Area Science Park (Riccardo Priore and Marinella Favot) and the University of Milan-Bicocca (Marco Compagnoni), China remains the most dynamic market in the REE recycling sector and Chinese universities are the main players in innovation, demonstrating a strong commitment to research and development of new technologies for the recovery of these materials. However, the United States and Japan emerge as technological leaders, with patents that are more frequently mentioned and with greater international protection of their inventions, indicating more advanced and globally relevant technological innovation.
Europe, on the other hand, shows signs of stagnation in both the number and quality of patents. To bridge the gap with the main players in the sector, greater support for innovation is needed through public investment, business incentives and international collaborations. Moreover, revising policies for managing waste of electric and electronic equipment (WEEE), which is rich in critical raw materials, is crucial to making the circular economy more effective, by improving waste collection, enhancing recycling facilities and incentivising the use of secondary raw materials.
Riccardo Priore of the Patlib Centre, at Area Science Park, states that “This study represents an innovative type of support, through statistical analysis of patent documents, to various issues related to academic research activities. The study of innovation dynamics in the rare earth recycling sector provides an important starting point for developing more effective strategies in the REE recycling sector, with significant implications for the strategic autonomy of importing countries and for the future of the global circular economy.”
In a context of increasing demand for rare earth elements, recycling capacity will become increasingly crucial in reducing dependence on imports and mitigating the environmental impact of extraction. The results of the study suggest that, in order to remain competitive, Western countries should intensify their efforts in the recycling sector by promoting high-quality innovations and investing in the transition to a more sustainable economy.
Link to the paper
Innovation services
Press releases
10.03.2025
Unlocking green hydrogen: focusing on research and recycling
To achieve the “zero emissions” target, emerging technologies such as green hydrogen are essential. However, the production of green hydrogen through electrolysis depends on critical raw materials (CRM), for which the demand is increasing, while supply remains concentrated in just a few countries. The study was presented at the “IRTC25: From Raw Material Policies to Practice” conference held in Ljubljana, supported by EIT RawMaterials (European Union) and the Federal Department of Economic Affairs (Switzerland). The research, conducted by Area Science Park (Riccardo Priore and Marinella Favot) and the University of Milano-Bicocca (Marco Compagnoni) within the North Adriatic Hydrogen Valley project – NAHV, explored two key aspects: technological innovation in green hydrogen through the analysis of patents and the assessment of the criticality of the raw materials necessary.
To identify global trends in green hydrogen innovation, patents related to key technologies such as fuel cells and electrolysers were analysed. Additionally, the criticality of the raw materials necessary for these technologies was assessed based on the EU’s list of critical raw materials.
Thanks to the PatLib Centre at Area Science Park, the study used a patent database (PATSTAT) covering the period from 2000 to 2023, focusing on:
temporal trends in patents for fuel cells and electrolysers
countries with the strongest interest in intellectual property protection on these topics
the most used critical raw materials and their trends over time.
The picture that emerged is the following:
patent applications for hydrogen technologies have increased significantly, reaching 5,380 applications filed in 2022 (a figure that may continue to grow), making a total of over 45,600 applications from 2000 to 2023 (noting that the publication secrecy period for applications is 18 months);
China, Japan and the USA are the territories most interested in the legal protection (via patents) of the production or commercialisation of key green hydrogen technologies;
13% of patents mention at least one critical raw material, with Nickel, Platinum and Lithium as the most important for both technologies (fuel cells and electrolysers).
The researchers conclude that while the increase in patent applications highlights a global push towards green hydrogen-based solutions, the dependency on critical raw materials such as Nickel, Platinum and Lithium raises concerns about supply risks, price volatility and geopolitical dependencies. To ensure the sustainable growth of hydrogen technologies, it will be crucial to develop new research into alternative materials and, at the same time, effective recycling strategies and supply chains.
Innovation services
Press releases
05.03.2025
Recycling Yttrium from electronic waste: an opportunity for the pharmaceutical industry
An innovative solution for the recovery and reuse of yttrium, a rare and critical chemical element, from electronic waste, has emerged from research conducted by Area Science Park and the University of Udine, presented at the “IRTC25” conference in Ljubljana. The study, conducted by Marinella Favot, Roberta Curiazi and Antonio Massarutto, demonstrates how Yttrium Triflate (Y(OTf)₃), a widely used catalyst in the pharmaceutical industry, can be produced in a cost-effective and environmentally friendly way from waste materials.
Yttrium and its compounds play a crucial role in numerous chemical and technological processes within the pharmaceutical sector. This element is used as a catalyst in key reactions for the synthesis of pharmaceutical intermediates, such as hydrolysis, condensation and oxidation-reduction reactions. Thanks to its high efficiency, yttrium triflate, in particular, makes it possible to reduce reaction times and improve chemical process yield, making it indispensable for the production of complex molecules that form the basis of many medicines.
As well as its use as a catalyst, yttrium is used in advanced technologies such as solid-state lasers, used in medical devices for surgery and diagnostics (YAG – Yttrium Aluminium Garnet lasers), in medical imaging techniques (including positron emission tomography – PET) and in biocompatible materials used in medical devices. Additionally, yttrium is used in the production of ceramics, LCD (Liquid Crystal Display) and plasma screens, cathode ray tubes (CRT), automotive catalysts, fluorescent lamps, permanent magnets and metallic alloys for batteries, as well as in fuel cells and electrolysers (key green hydrogen technologies), primarily in the form of yttria-stabilised zirconia (YSZ).
Recycling Yttrium from Electronic Waste: A Sustainable Solution
The research presented at the “IRTC25” conference focuses on recovering yttrium oxide, which is present in small quantities in electronic waste, and transforming it into yttrium triflate through a three-stage process: catalyst synthesis, filtration and water removal. Although the final product is not 100% purified, it has proven to be effective and economically sustainable compared to purchasing pure yttrium triflate on the market.
“The recycling process not only reduces dependence on virgin raw materials but it also represents a cost-effective solution”, explains Marinella Favot of Area Science Park. “In fact, recovering yttrium from electronic waste is more cost-effective than traditional disposal methods, especially when the price of the recovered material exceeds the costs of collection and treatment.”
This research has been selected for a pitch at Apple and McKinsey’s “Talent meets Industry” event and represents a significant step towards a more sustainable circular economy, reducing the environmental and social impact linked to rare earth extraction and improving the resilience of supply chains. However, some challenges remain, such as the volatility of the prices of pure materials and the need to develop infrastructures for the treatment of electronic waste in Europe. In a global context where the demand for critical materials such as yttrium is constantly increasing, the recycling of electronic waste is confirmed as a key strategy for ensuring a more sustainable future and reducing environmental impact, also in pharmaceutical production.
Innovation services
Press releases
08.01.2025
A guide for integrated and sustainable energy, climate and spatial planning
A guideline to support European local and regional authorities in drafting, implementing and monitoring territorial plans that integrate aspects of energy, climate and mobility, aimed at achieving climate neutrality in a multilevel governance perspective.
It was drawn up by the IN-PLAN project team, co-funded by the European Union’s LIFE Programme, to support local authorities who often struggle to convert climate objectives into concrete actions.
The IN-PLAN methodology suggests an integrated and collaborative approach combining sectoral plans (e.g. renewable energy, sustainable mobility and climate adaptation) and urban plans in a single spatial planning strategy. It also encourages collaboration among local, regional and national levels of government, fostering greater coherence and the allocation of adequate resources for climate actions. All this is in line with European initiatives, such as the Green Deal and the EU Climate Law, in support of the objectives of reducing emissions and achieving climate neutrality.
There are several key elements in the IN-PLAN Guidelines, co-created, developed and tested with 15 local authorities in Italy, Croatia, Ireland, Romania and Sweden, and now being implemented and spread to another 30 European municipalities:
Integrated planning: it incorporates energy and climate objectives in spatial development plans, addressing key issues such as sustainable mobility, renewable energy and climate adaptation;
Political commitment: it ensures collaboration among local, regional and national governments to obtain long-term support and dedicated resources for sustainable initiatives, with a view to multi-level governance;
Skill building: it provides a two-phase training programme first for energy and climate agencies and consultants, who will then assist local and regional governments in developing their own spatial plans, thus guaranteeing knowledge transfer and replicability of the IN-PLAN model across Europe;
User-friendly checklists: The checklists guide municipalities in the process of integrating energy and climate objectives into their spatial plans, making sure that effective measures to achieve climate neutrality are planned and implemented.
“As climate change continues to present unprecedented challenges, it is crucial that local governments have tools available that are not only aligned with national and EU policies, but that also respond to the specific needs of their territories,” explains Fabrizia Salvi of Area Science Park. “Despite ambitious climate neutrality goals, many local and regional authorities face persistent challenges in converting these goals into concrete actions.”
As the European Union strives to achieve climate neutrality by 2050, a tool like the IN-PLAN practice provides towns and regions with the tools they need to actively take steps towards a sustainable future, ensuring that climate goals are not only set, but also achieved through concrete and integrated actions. This support tool is already being tested with 15 local and regional authorities, called “Lighthouses”, and 30 more municipalities will be involved as “Pilots”, making it possible to adapt and replicate the methodology all across Europe.
The Municipality of Prato, which is taking part in the European mission “100 Climate-Neutral and Smart Cities by 2030”, is working on the harmonisation of the new Municipal Structural Plan with the Sustainable Urban Mobility Plan according to the measures indicated in the Climate City Contract. “In 2022, a governance structure was defined to coordinate urban planning, mobility and energy that developed policy measures for drafting the Climate City Contract – explains architect Riccardo Pallini, manager of the Mobility and Infrastructure Sector -. These indications were also the basis for drafting the new Structural Plan and a new Sustainable Urban Mobility Plan (SUMP); in this way, the theme of sustainable mobility was already present in the guidelines for the drafting of the new Structural Plan, and the new SUMP of the Municipality of Prato can thus be developed in close relation with the indications of the Structural Plan and the Climate City Contract”.
Interdepartmental collaboration has begun in Narni to deal with the challenges of complexity. “It is important for medium-small municipalities to have the opportunity to learn good practices, even if implemented in large municipalities, which then need to be adapted to the local situation, striving to remove some administrative barriers,” says Giovanni Rubini, Council member for Environmental Policies. There is a need for cultural change and simplified regulations; we need skills, a long-term vision, the possibility of establishing contacts with the Regions and Ministries, and a central coordination role for the provinces. The availability of resources is also a problem and if we want to encourage the development of monitoring plans, rewards should be provided that favour the most virtuous Municipalities.”
The city of Padua is also committed to implementing ambitious integrated plans to achieve climate neutrality by 2030. “Data and a cross-sectoral approach are needed in order to address the challenges of implementing these plans,” says Giovanni Vicentini, technical official with the Environment and Territory Sector. The Municipalities do not have all the data and usually, even within these municipalities, each departmental area has data that could be useful to others. Data is essential for developing a detailed overview, and the barriers are not technological.”
The Guideline will also be further explored within the National Round Table for Discussion (National Coalition Group) of the IN-PLAN project, an activity launched in December 2024, offering a unique opportunity for various stakeholders to exchange views and make recommendations on integrated planning to be subsequently shared with national policy-makers. Participation in the Round Table, which does not require any formal membership, is conceived as an open space for discussion and debate and foresees further online meetings during 2025.
The IN-PLAN Guideline is available here.
Further information about the IN-PLAN project is available here.
Innovation services
Press releases
28.11.2024
Research: strengthened scientific collaboration between Italy and Serbia
Scientific collaboration between Italy and Serbia is being strengthened. The Minister of University and Research, Anna Maria Bernini, and the Serbian Minister of Science, Technological Development, and Innovation, Jelena Begović, inaugurated the second Italy-Serbia Scientific Forum in Trieste at Area Science Park, with the participation of over 100 researchers from both countries.
Following a bilateral meeting, the ministers signed a joint declaration confirming the importance of cooperation in research and innovation, based on the MoU signed in Belgrade in 2023, as well as the promotion of researcher mobility, support for joint research programs, and bilateral scientific events. The document also highlighted the great success of the first call for joint research projects focused on the following areas: High Performance Computing and Big Data, Artificial Intelligence, Agri-food Technologies, and Sustainable Economy. Over 80 applications were received and are currently under evaluation. The selected projects will be co-financed by both countries (for a total of 2 million euros) at the beginning of 2025.
Today’s event continues the path started in March 2023 in Belgrade when Area Science Park participated in the first edition of the Science Forum. In December 2023, during the Innovation Forum, a Memorandum of Understanding was signed in the capital between Area Science Park and the science and technology parks of Belgrade, Niš, Čačak, and Novi Sad. This memorandum further develops a longstanding cooperation with Serbia that began in 2015, focusing on technical assistance in the fields of technology transfer and economic development. The goal is to pool scientific and technological capacities, such as those generated by research infrastructures and technological platforms, for example, on topics like life sciences, energy transition, and innovative materials.
“The Italy-Serbia scientific forum represents, for Area Science Park and for the entire Scientific and Innovation System of Friuli Venezia Giulia, an important opportunity to strengthen collaboration between the two countries and create new opportunities for the exchange and sharing of knowledge and best practices,” said Caterina Petrillo, President of Area Science Park. “In particular, for the institution I lead, hosting, and especially participating in the forum, means expanding the areas of exchange and dialogue with research centers, universities, and science and technology parks, with which we have previously developed innovation projects. Today, our attention is focused on research and technological infrastructures, where Area has been investing in recent years, which by their nature are places for aggregation and sharing of knowledge.”
Institutional
Press releases
27.11.2024
Ultrasound technology to treat liver cancer: Soundsafe Care wins 2024 Startup Marathon
A robotic device that uses ultrasound technology to treat liver cancer, one of the world’s leading causes of death, with over 900,000 cases every year. The Pisa-based startup Soundsafe Care has won first prize in the 2024 Startup Marathon. The startup competition, promoted by Area Science Park, UniCredit and Fondazione Comunica, ended on Tuesday, 26 November, with an event hosted at the UniCredit headquarters in Milan. Ten finalists were selected by a jury of entrepreneurs, investors and industry experts, from a pool of over 60 startups and innovative SMEs, enrolled in the competition by incubators, accelerators, research centres and universities all over Italy.
Awards for Startups
Operating in the artificial intelligence, innovative materials, nutraceutical, agritech, healthcare, gaming, electric mobility and medical innovation sectors, the ten startups competed for access to the UniCredit Start Lab acceleration programme. The overall winner, Soundsafe Care, is a company supported by the Navacchio Technology Hub. Using focused ultrasound, the device developed by the startup provides a non-invasive and drug-free alternative for the treatment of liver cancer, reducing complications and hospital costs. Thanks to advanced imaging and automation technology, the device improves treatment precision and reduces intervention times. Soundsafe Care also received the award for the best predominantly female startup, guaranteeing participation in the BoostHerUp internationalisation programme, promoted by Area Science Park.
In second place was another med-tech startup, Impavid from Turin, nominated for the contest by G-Factor, the Fondazione Golinelli business incubator. Impavid develops an innovative biodegradable cardiac patch to combat post-ischaemic heart failure. This biomimetic and bioresorbable patch recreates the structure of myocardial tissue, promoting cell recovery and adapting to the heart’s rhythm. Initially designed for bypass procedures, it offers a safer and less invasive solution to improve patients’ quality of life. With strong potential in the US and European markets, the product responds to the growing demand for advanced cardiology technologies.
Ranked third, the Lecce-based BeadRoots – supported by Eatable Adventures – develops a natural and biodegradable hydrogel derived from algae. This hydrogel efficiently retains and releases water to improve agricultural productivity and reduce water wastage, especially in areas affected by drought. Unlike synthetic products, the gel is eco-friendly and supports soil microorganisms without negative impacts.
The startups on the podium will have the opportunity to enjoy privileged access to the pre-selection stage for the national mission at CES in Las Vegas.
Awards for support organisations
The top three business support organisations that nominated startups for the event were also rewarded. Points were assigned based on the ranking of the startups, with a bonus for the placement of predominantly female startups. The first prize went to the Polo Tecnologico di Navacchio, followed by G-Factor in second place and Eatable Adventures in third place. All three were granted privileged access to the Executive MBA in Business Innovation created by the MIB Trieste School of Management. This same recognition was awarded individually to all 10 finalist startups.
The 2024 edition also introduced the Open Innovation B2B competition, which challenged startups and innovative SMEs to respond to specific innovation needs indicated by corporate partners of the initiative.
“We are very pleased with this fifth edition of Startup Marathon”, said Roberto Pillon, head of the Business Generation Office at Area Science Park. “The startups selected for the finals operate in very diverse sectors, showing how innovation is a cross-cutting element in every market and how initiatives like this can support its development. Today, the transformative capabilities of technology, with the even greater potential of the deep-tech sector, have an enormous impact on every industry: a scenario that can be expressed in full through close collaboration between producers of innovation and businesses capable of leveraging it.”
Renzo Chervatin, head of Territorial Development for UniCredit North Est, stated: “There are many reasons to feel satisfied with the 2024 edition of Startup Marathon, particularly the creation of a virtuous ecosystem made up of corporate companies, investors and numerous accelerators and incubators at the national level. As UniCredit, we have made available the know-how gained in over a decade as pioneers and leaders supporting the world of Italian startups, with the intent of reaffirming, in practice, our commitment to work alongside those who want to invest in innovation, by proposing growth opportunities to businesses and jobs to young people.”
Gianni Potti, President of Fondazione Comunica and founder of DIGITALmeet, added: “This is a brilliant demonstration of digital literacy, one of the biggest challenges for the country. In addition to this, there are also innovation and entrepreneurial skills, requirements that the Jury used for the 2024 edition of Startup Marathon: as of September, there were 16,500 innovative startups in Italy; at the same time, there were nearly 200 thousand in Europe, concentrated in the technology, sustainability, digital health and artificial intelligence sectors. Startups are a fundamental driving force for the future, thanks to their ability to innovate, adapt and transform entire sectors.”
“This is yet another demonstration of an idea that turned out to be spot on”, commented Antonio Bassi and Maurizio Caradonna, founders of Startup Marathon, “The Startup Marathon final, attended by a high-profile audience, showcased entrepreneurial ventures with great opportunities for development and teams with high-level skills and technological knowledge, supported by organisations that aim to create high-potential businesses throughout the nation. We are proud to have contributed, even in a small way, to encouraging the growth of this innovation ecosystem”.
Startup Marathon was founded in 2020 and, over the years, it has selected and rewarded innovative companies operating in sectors such as artificial intelligence, diagnostics, IoT and sustainability. Winners of past editions include Katakem, a spin-off of the University of Catanzaro, that accelerates the development of new molecules, CAEmate, a company that has developed software for the predictive maintenance of infrastructures, Aisent, which provides services based on AI, machine learning and computer vision, and M2Test, a spin-off of the University of Trieste that has created an innovative method for diagnosing osteoporosis.
Partners
In addition to the three promoters, several partners support Startup Marathon, including Angel For Women, ASAC, Avvio Capital, Bando Easy, Camst Group, Carel, Chiesi, CRCLEX, DBA Group, Eatable Adventures, ELIS Innovation Hub, Eurotherm, Fastweb, FITT, Galdi, Giordano Controls, HiRef, Italian Angels for Growth, Italian Business Angels Network, LIFTT, Manni Group, Master Builders Solutions, Mastercard, Maxfone, MIB Trieste School of Management, MITO Tech Ventures, One Factory, San Marco Group, Star Tech Ventures, Step, Unicorn Trainers Club, Venture Factory and WDA.
The Finalist Startups and their Supporting Organisations
BeadRoots, Lecce, supported by Eatable Adventures
Cartesia Solutions, Pisa, supported by Digital Hub
Impavid, Turin, supported by G-Factor
InnoItaly, Codognè (Treviso), supported by Trentino Sviluppo
Joule, Campodarsego (Padua), supported by Seedble
Northern Light Composites, Monfalcone (Gorizia), supported by TEC4I FVG
NuHpro, Rimini, supported by CesenaLab
SoundSafe Care, Pisa, supported by Polo tecnologico di Navacchio
Weabios, Pisa, supported by Polo tecnologico di Navacchio
Witty Power, Bolzano, supported by NOI Techpark
Startup Marathon is a competition for innovative businesses, open to startups, innovative SMEs and university spin-offs nominated by business incubators and accelerators. Promoted by Area Science Park, UniCredit and Fondazione Comunica, it has been selecting the most significant innovative Italian companies since 2020, accelerating their go-to-market journey.
Innovation services
Press releases
20.11.2024
Metallic atoms in graphene networks: how the materials of the future are born
An international study, involving the Italian National Research Council (CNR – Istituto Officina dei Materiali) and the Universities of Trieste and Milano-Bicocca for Italy, along with the University of Vienna, has unveiled a simple and innovative method for creating a new category of materials. These materials combine the exceptional properties manifested by individual metal atoms with the robustness, flexibility and versatility of graphene, for potential applications in the fields of catalysis, spintronics and electronic devices.
The study is published in Science Advances: the method involves depositing metal atoms, such as cobalt, in a controlled manner, during the formation of the graphene layer on a nickel surface. Some of these atoms are incorporated into the carbon network of graphene, forming a new material with exceptional robustness, reactivity and stability.
The method was developed at the CNR-IOM laboratories in Trieste: “This is still a preliminary result, but it is already very promising and the result of an original idea that arose in our laboratory and initially seemed unfeasible,” says Cristina Africh, a researcher at the CNR-IOM who led the team.
The material’s ability to detach from the substrate while maintaining its original structure makes it potentially usable in various applications. “The methodology has been tested for trapping nickel and cobalt atoms, but our calculations suggest that it could be extended to other metals for different applications,” explains Cristiana Di Valentin, professor of General and Inorganic Chemistry at the University of Milano-Bicocca.
Moreover, the material has proven to be stable even under critical conditions. “We have demonstrated that this material remains intact even in critical conditions, including the electrochemical environments used for applications in fuel cells and batteries,” adds Jani Kotakoski of the University of Vienna.
The study, which is the result of international collaboration, made use of different and complementary skills. “This aspect was decisive in demonstrating the effectiveness of this approach, which is simple and powerful at the same time,” concludes Giovanni Comelli from the University of Trieste.
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Press releases
Research infrastructures
15.10.2024
New Frontiers of Artificial Intelligence in Protein Research
The Data Engineering Laboratory (LADE) at Area Science Park has recently published an innovative study into Bioinformatics, opening up new perspectives in the study of proteins, the fundamental building blocks of life. In fact, Francesca Cuturello, Marco Celoria, Alessio Ansuini and Alberto Cazzaniga, the authors of the study, have demonstrated how artificial intelligence can predict the impact of genetic mutations on protein stability, helping to get a better understanding of the mechanisms underlying many diseases and potentially developing new treatments. The genome of living beings is constantly mutating due to external agents or random events and this leads us to observe changes in the sequences of the proteins they synthesise.
Conducted as part of the Pathogen Readiness Platform for CERIC-ERIC (PRP@CERIC) project, the study uses AI models similar to GPT, applied to proteomics. These models are based on the analogy between a protein sequence and a sentence, with amino acids acting as “words”, allowing algorithms trained on hundreds of millions of protein sequences to be applied. Using this technique, the LADE researchers were able to predict how small variations in the amino acid sequence, such as those induced by mutations, can affect protein stability.
A particularly innovative aspect is the use of the MSA Transformer model, which utilises information on the ancestral relationships between protein sequences to enhance the accuracy of predictions. The algorithm developed by LADE offers cutting-edge performance and will be made available to the scientific community to encourage further advancements in this field.
“Predicting the effect of protein mutations through artificial intelligence allows us to explore, with great precision, complex biological phenomena that, until recently, were difficult to observe directly”, explains Francesca Cuturello, the study’s lead author. “This technology is a step forward towards innovative therapeutic solutions for a wide range of diseases.”
The team’s work has already received widespread recognition, including Francesca Cuturello’s invitation to the prestigious Research Retreat “Physics of Biological Data Analysis” at the Aspen Center for Physics and it will be presented at other international research centres, such as the ICTP and the Leibniz Center for Informatics.
For more information about LADE’s activities, click here.
Press releases
Technological Infrastructures